Scientific publications
 

2026

Jaimes-Campos MA, Stroggilos R, Schanstra JP, Vlahou A, Brunet M, Jonas J-C, Bensellam M, Mischak H, Latosinska A. Pan-Fibrotic Gene Expression Signature in Major Chronic Diseases by Integrative Bulk and Single-Cell Transcriptomic Analyses. International Journal of Molecular Sciences. 2026; 27(19):8755. doi: 10.3390/ijms27198755.

https://www.mdpi.com/1422-0067/27/19/8755

Mina IK, Hussain Y, Siwy J, Catanese L, Rupprecht H, Beige J, Staessen JA, Metzger J, Persson F, Rossing P, Delles C, Schanstra JP, Bannaga A, Vlahou A, Mischak H, Arasaradnam RP, Latosinska A. Urinary collagen type I degradation products as common fibrosis biomarkers in chronic diseases. Mol Med. 2026 Sep 23;32(1):158. doi: 10.1186/s10020-026-01648-5. PMID: 42778889; PMCID: PMC13602581.

https://pubmed.ncbi.nlm.nih.gov/42778889

Gao Y, Lorentzen LG, Martin EM, Genovese F, Faustmann G, Grabher-Moser J, Tiran B, Winklhofer-Roob BM, Davies MJ. Proteomic analysis of plasma and extracellular vesicles from subjects with impaired vascular health. Biosci Rep. 2026 Sep 16;46(9):BSR20260067. doi: 10.1042/BSR20260067. PMID: 42566301. 

https://pubmed.ncbi.nlm.nih.gov/42566301

Frantzi M, Keller F, Latosinska A, Beige J, Mebazaa A, Caillard A, An D, Perco P, Schanstra JP, Catanese L, Wendt R, Rupprecht H, Staessen JA, Vlahou A, Mischak H, Siwy J. Urinary Collagen Peptides Predict Mortality. Proteomics 2026 Jul;26(7):98-110. doi: 10.1002/pmic.70131. Epub 2026 Apr 9. PMID: 41954080; PMCID: PMC13327709 

https://pubmed.ncbi.nlm.nih.gov/41954080

Frattini T, Breuil B, Buléon M, Feuillet G, Chabbert M, Delecroix E, Froment C, Burlet-Schiltz O, Sylla B, Mischak H, Mina IK, Siwy J, Latosinska A, Saulnier-Blache JS, Schanstra J. Reduced collagen degradation in pelvic urine precedes kidney fibrosis induced by unilateral ureteral obstruction. Sci Rep. 2025 Nov 21. doi: 10.1038/s41598-025-29217-6. Epub ahead of print. PMID: 41272289. 

https://pubmed.ncbi.nlm.nih.gov/41272289

Martin EM, Angeli E, Genovese F, Frydland M, Karsdal MA, Møller JE, Hassager C. Collagen type I degradation peptide as a predictive biomarker for mortality in ST-elevated myocardial infarction. Clin Res Cardiol. 2026 Mar 4. doi: 10.1007/s00392-026-02883-w. Epub ahead of print. PMID: 41779128. 

https://pubmed.ncbi.nlm.nih.gov/41779128

2025

Boukhaled JH, Martin EM, Gayrard N, Argilés À, Karsdal MA, Genovese F. Scarred by Fibrosis: The Heart-Kidney Disease Connection. Annu Rev Physiol. 2025 Nov 4. doi: 10.1146/annurev-physiol-043024-115512. Epub ahead of print. PMID: 41187304.

https://pubmed.ncbi.nlm.nih.gov/41187304

Devos H, Makridakis M, Stroggilos R, Campos MAJ, Tserga A, Mokou M, Roubelakis MG, Zoidakis J, Vlahou A, Latosinska A. A Proteomics Resource Investigating Fibrosis: Proof-of-Concept for Identifying Novel Drug Candidates. Proteomics. 2026 Jan;26(1):94-99. doi: 10.1002/pmic.70090. Epub 2025 Dec 12. PMID: 41386747; PMCID: PMC12809004.

https://pubmed.ncbi.nlm.nih.gov/41386747

Gayrard N, Plawecki M, Lauret C, Fila M, Sicard P, Duranton F, Boukhaled JH, Cortijo-Tejero I, Lotierzo M, Jover B, Cristol JP, Raynaud F. Heart dysfunction in a rat model with autosomal recessive polycystic kidney disease. J Physiol. 2025 May;603(9):2551-2567. doi: 10.1113/JP286364. Epub 2025 Apr 11. PMID: 40214648. 

https://pubmed.ncbi.nlm.nih.gov/40214648

Biglari S, Mischak H, Beige J, Latosinska A, Siwy J, Banasik M. The Future of Chronic Kidney Disease Treatment: Combination Therapy (Polypill) or Biomarker-Guided Personalized Intervention? Biomolecules. 2025 Jun 3;15(6):809. doi: 10.3390/biom15060809. PMID: 40563449; PMCID: PMC12190282.

https://pubmed.ncbi.nlm.nih.gov/40563449

Mischak H, Schanstra JP, Vlahou A, Beige J. Clinical Proteomics, Quo Vadis? Proteomics. 2025 Apr;25(7):e202400346. doi: 10.1002/pmic.202400346. Epub 2025 Feb 9. PMID: 39924729; PMCID: PMC11962580. 

https://pubmed.ncbi.nlm.nih.gov/39924729

Latosinska A, Mina IK, Nguyen TMN, Golovko I, Keller F, Mayer G, Rossing P, Staessen JA, Delles C, Beige J, Glorieux G, Clark AL, Schanstra JP, Vlahou A, Peter K, Rychlík I, Ortiz A, Campbell A, Rupprecht H, Persson F, Mischak H, Siwy J. In silico prediction of optimal multifactorial intervention in chronic kidney disease. J Transl Med. 2025 Aug 21;23(1):943. doi: 10.1186/s12967-025-06977-3. PMID: 40842026; PMCID: PMC12372250.

https://pubmed.ncbi.nlm.nih.gov/40842026


Devos H, Mina IK, Paradeisi F, Makridakis M, Tserga A, Mokou M, Zoidakis J, Mischak H, Vlahou A, Latosinska A, Roubelakis MG. A Naturally Occurring Urinary Collagen Type I Alpha 1-Derived Peptide Inhibits Collagen Type I-Induced Endothelial Cell Migration at Physiological Concentrations. Int J Mol Sci. 2025 Aug 2;26(15):7480. doi: 10.3390/ijms26157480. PMID: 40806611; PMCID: PMC12347341.

https://pubmed.ncbi.nlm.nih.gov/40806611


Bartochowski P, Cortijo I, Bhargava S, Jover B, Raynaud F, Boukhaled JH, Lajoix AD, Jankowski V, Jankowski J, Cordaillat-Simmons M, Argilés À, Gayrard N, Duranton F, Laget J. Gut alterations in a chronic kidney disease rat model with diet-induced vascular calcification. FEBS Open Bio. 2025 Aug;15(8):1219-1231. doi: 10.1002/2211-5463.70043. Epub 2025 Jun 17. PMID: 40526091; PMCID: PMC12319703.

https://pubmed.ncbi.nlm.nih.gov/40526091


Martin EM, Genovese F, Mischak H, Siwy J, Rupprecht H, Catanese L, Latosinska A. Association of Urinary Collagen Type III Degradation Product With Kidney Function and Fibrosis in Chronic Kidney Disease Patients. Proteomics. 2025 Jun;25(11-12):e202400354. doi: 10.1002/pmic.202400354. Epub 2025 Apr 10. PMID: 40211596; PMCID: PMC12205290.

https://pubmed.ncbi.nlm.nih.gov/40211596


Martin EM, Chang J, González A, Genovese F. Circulating collagen type I fragments as specific biomarkers of cardiovascular outcome risk: Where are the opportunities? Matrix Biol. 2025 May;137:19-32. doi: 10.1016/j.matbio.2025.03.001. Epub 2025 Mar 2. PMID: 40037418; PMCID: PMC11986567.

https://pubmed.ncbi.nlm.nih.gov/40037418

Lopes MB, Coletti R, Duranton F, Glorieux G, Jaimes Campos MA, Klein J, Ley M, Perco P, Sampri A, Tur-Sinai A. The Omics-Driven Machine Learning Path to Cost-Effective Precision Medicine in Chronic Kidney Disease. Proteomics. 2025 Jan 10:e202400108. doi: 10.1002/pmic.202400108. Epub ahead of print. PMID: 39790049.

https://pubmed.ncbi.nlm.nih.gov/39790049

2024

Mina IK, Iglesias-Martinez LF, Ley M, Fillinger L, Perco P, Siwy J, Mischak H, Jankowski V. Investigation of the Urinary Peptidome to Unravel Collagen Degradation in Health and Kidney Disease. Proteomics. 2024 Dec 30:e202400279. doi: 10.1002/pmic.202400279. Epub ahead of print. PMID: 39740102.

https://pubmed.ncbi.nlm.nih.gov/39740102

 Jaimes Campos MA, Kabić S, Latosinska A, Anicic E, Siwy J, Dragušica V, Rupprecht H, Catanese L, Keller F, Perco P, Gomez- Gomez E, Beige J, Vlahou A, Mischak H, Vukelić D, Križan T, Frantzi M. A synthetic data generation pipeline to reproducibly mirror high-resolution multi-variable peptidomics and real-patient clinical data. medRxiv 2024.10.30.24316342.

https://www.medrxiv.org/content/10.1101/2024.10.30.24316342v1

Frattini T, Devos H, Makridakis M, Roubelakis MG, Latosinska A, Mischak H, Schanstra JP, Vlahou A, Saulnier-Blache JS. Benefits and limits of decellularization on mass-spectrometry-based extracellular matrix proteome analysis of mouse kidney. Proteomics. 2024 Sep;24(17):e2400052. doi: 10.1002/pmic.202400052. Epub 2024 Jun 19. PMID: 38896836.

https://pubmed.ncbi.nlm.nih.gov/38896836

2023

Jaimes Campos MA, Mavrogeorgis E, Latosinska A, Eder S, Buchwinkler L, Mischak H, Siwy J, Rossing P, Mayer G, Jankowski J. Urinary peptide analysis to predict the response to blood pressure medication. Nephrol Dial Transplant. 2023 Oct 31:gfad223. doi: 10.1093/ndt/gfad223. Epub ahead of print. PMID: 37930730. 

https://pubmed.ncbi.nlm.nih.gov/37930730

Please take a moment to check out the related video as well!

https://www.youtube.com/watch?v=o27WHYCCbv4&t=3s

Mina IK, Mavrogeorgis E, Siwy J, Stojanov R, Mischak H, Latosinska A, Jankowski V. Multiple urinary peptides display distinct sex-specific distribution. Proteomics. 2023, 26:e2300227. doi: 10.1002/pmic.202300227. Epub ahead of print. PMID: 37750242.

https://pubmed.ncbi.nlm.nih.gov/37750242

Keller F, Beige J, Siwy J, Mebazaa A, An D, Mischak H, Schanstra JP, Mokou M, Perco P, Staessen JA, Vlahou A, Latosinska A. Urinary peptides provide information about the risk of mortality across a spectrum of diseases and scenarios. J Transl Med. 2023, 21(1):663. doi: 10.1186/s12967-023-04508-6. PMID: 37741989; PMCID: PMC10518109.

https://pubmed.ncbi.nlm.nih.gov/37741989/4

Jaimes Campos MA, Andújar I, Keller F, Mayer G, Rossing P, Staessen JA, Delles C, Beige J, Glorieux G, Clark AL, Mullen W, Schanstra JP, Vlahou A, Rossing K, Peter K, Ortiz A, Campbell A, Persson F, Latosinska A, Mischak H, Siwy J, Jankowski J. Prognosis and Personalized In Silico Prediction of Treatment Efficacy in Cardiovascular and Chronic Kidney Disease: A Proof-of-Concept Study. Pharmaceuticals (Basel). 2023, 16(9):1298. doi: 10.3390/ph16091298. PMID: 37765106; PMCID: PMC10537115.

https://pubmed.ncbi.nlm.nih.gov/37765106

Laget J, Cortijo I, Boukhaled JH, Muyor K, Duranton F, Jover B, Raynaud F, Lajoix AD, Argilés À, Gayrard N. Cafeteria Diet-Induced Obesity Worsens Experimental CKD. Nutrients. 2023, 15(15):3331. doi: 10.3390/nu15153331. PMID: 37571269; PMCID: PMC10421241.

https://pubmed.ncbi.nlm.nih.gov/37571269

Devos H, Zoidakis J, Roubelakis MG, Latosinska A, Vlahou A. Reviewing the Regulators of COL1A1. Int J Mol Sci. 2023, 24(12):10004. doi: 10.3390/ijms241210004. PMID: 37373151; PMCID: PMC10298483.

https://pubmed.ncbi.nlm.nih.gov/37373151