Discovering Collagen I degradation process in chronic diseases with fibrotic component 

DisCo-I will train young and ambitious scientists to combat major chronic diseases with fibrotic component by offering them a comprehensive and inter-sectoral training to change our view on the driving force for fibrosis: from a disease of enhanced production of extracellular matrix to a disease of failing extracellular matrix degradation. 

Collagens are most abundant components of extracellular matrix, with type I collagen being a predominant component of fibrotic tissue and having an emerging role in chronic diseases. 

Thus, young scientists will focus on delivering currently missing fundamental knowledge on the molecular pathophysiology of type I collagen degradation, setting up a stage for non-invasive diagnostic biomarkers of fibrosis and novel anti-fibrotic therapies, thus decreasing the burden of chronic diseases in the future.

The DisCo-I project has received funding from the European Union’s Horizon Europe Marie Skłodowska-Curie Actions Doctoral Networks - Industrial Doctorates Programme (HORIZON – MSCA – 2021 – DN-ID) under grant agreement No 101072828.

Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union. Neither the European Union nor the granting authority can be held responsible for them.



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